Natural Health Remedies For Antibiotic Resistant Infections

Date: 12/05/2005    Written by: Jon Barron

Why Antibiotics And Antivirals Fail

The latest issue of the CDC's Morbidity and Mortality Weekly Report features a story about a deadly bacterial illness commonly seen in people on antibiotics but that now appears to be growing more common in patients not taking such drugs. The bacterium is Clostridium difficile, also known as C-diff. It's symptoms include diarrhea, fever, abdominal pain, loss of appetite and nausea, and last year it was blamed for 100 deaths over 18 months in just one hospital in Quebec, Canada. And in a second article in the New England Journal of Medicine, health officials said samples of the same bacteria taken from eight US hospitals show it's mutating to become even more resistant to antibiotics. Especially disturbing, according to the Centers for Disease Control and Prevention, recent cases in four states indicate it's now appearing more often in healthy people who have not been admitted to health-care facilities or even taken antibiotics. The bottom line is that C-diff has grown resistant to antibiotics that work against other colon bacteria. How did this happen? Quite simply, when patients took those antibiotics, particularly clindamycin, competing bacteria died off and C-diff exploded.

But this article isn't about C-diff. C-diff is merely the headline trigger. What we want to talk about is why and how bacteria like C-diff and viruses like bird flu develop resistance to antibiotics and antiviral drugs. And more importantly…what you can do about it.

Antibiotic Resistant Infections

Penicillin was discovered (actually rediscovered) by Dr. Alexander Fleming in 1928. But just four years after drug companies began mass-producing it in 1943, microbes began appearing that could resist it. Since then, we've seen penicillin-resistant strains of pneumonia, gonorrhea, and hospital-acquired intestinal infections join the list. And it's not just penicillin. Bacteria resistant to most of the other antibiotics of choice have also appeared and proliferated on a regular basis.

Antibiotic resistance to manmade drugs is almost impossible to stop since it is the result of some simple rules of evolution. Any population of organisms, bacteria included, naturally includes variants with unusual traits -- in this case, the ability to withstand a particular antibiotic's attack. When said antibiotic is used and kills the defenseless bacteria, it leaves behind those bacteria that can resist it. These renegade variants then multiply, increasing their numbers a million fold in a single day, instantly becoming the dominant variant. In other words, the very act of using an antibiotic creates the opportunity for strains resistant to it to flourish.

How do antibiotics work?

It's important to understand that antibiotics vary in the way they kill microbes. Penicillin, for example, kills bacteria by attaching to their cell walls and then breeching those walls, thus killing the bacteria. Erythromycin, tetracycline, and streptomycin, on the other hand, kill bacteria by attacking the structures inside the bacteria (ribosomes) that allow them to make proteins, thus also destroying the bacteria.

Unfortunately, because each antibiotic is a single compound and one dimensional in its approach, it's not that hard for microbes to "evolve" around such attacks. For example, microbes resistant to penicillin have developed cell walls different from the norm and that prevent the penicillin from binding. Similarly, other variants prevent antibiotics from binding to ribosomes, thus neutralize the effect of those antibiotics.

Again, because antibiotics are one dimensional in their approach, it's not that hard for microbes to "evolve" around them.

Where it gets really frightening, though, is that bacteria swap genes like politicians swap favors -- which brings us to vancomycin, the antibiotic of last resort. When all other antibiotics failed, doctors knew they could count on vancomycin. But then vancomycin resistance was discovered in a common hospital microbe, enterococcus. By 1991, 38 hospitals in the United States reported the variant. Just one year later, vancomycin resistant Staph bacteria were observed with the same gene. What this means is that not only are bacteria programmed to "evolve" defenses against antibiotics, but once they produce such a defense, they are also programmed to rapidly share that defense with other bacteria -- thus rapidly spreading the resistance.


Whereas bacteria are single-celled organisms, viruses are far simpler -- more primitive even. Essentially, viruses consist of one type of biochemical (a nucleic acid, such as DNA or RNA) wrapped in another (protein). Viruses are so primitive, in fact, that most biologists do not consider them to be living things, but instead, they are considered infectious particles. Since antibiotics specifically attack bacteria, they are useless against viruses. For viruses, doctors rely on a much less effective group of drugs called antivirals. Tamiflu, which governments are currently stockpiling as bird flu insurance, is one such antiviral.

Because of their primitive structure, viruses mutate even more easily than bacteria. Whereas antibiotics can remain effective for 2-5 years before resistant strains render them ineffective, antiviral resistant strains can appear in a matter of months, or even weeks. And in fact, we have seen that with Tamiflu. Although governments are stockpiling it as a safety net for bird flu, bird flu arrived on the scene pretty much resistant to Tamiflu and the other antivirals right out of the gate. And even those flus that Tamiflu was once helpful with are developing resistant strains by the month.

What can science do?

It was briefly thought that alternating the most commonly used antibiotics might stop the spread of antibiotic resistance. But a new model shows that the practice of cycling, alternating between two or more classes of antibiotics as often as every few months, probably will not work.

The latest theory is that mixing cocktails of antibiotics may help. And, in fact, this is closer to the way natural substances avoid the resistance problem.

How natural substances avoid the problem

When you think about how quickly pathogens "evolve around" antibiotic and antiviral drugs, it's more than amazing that they have been unable to do so against most natural antipathogens such as garlic, olive leaf, and oil of oregano even given tens of thousands of years to do so. How does this happen? What is their secret?

Actually, it's quite simple – or more accurately, quite complex. Earlier, we talked about how drugs are essentially one dimensional, which allows microbes an easy avenue to evolve around them. Natural antipathogens, on the other hand, are anything but one dimensional. They often contain dozens of biochemicals. Not all of them are "active," of course, but many of the so called non-active biochemicals work to potentiate the active ones and offer combinations with each other numbering in the thousands – presenting a complexity that makes it virtually impossible for microbes to work around.

Take garlic for example

For a long time, many people thought there was only one active component in garlic, allicin (in fact, many companies still promote that concept). It was believed that raw garlic had very little biological activity, but when you "damage" garlic cloves - by slicing, cooking, or chewing them - the enzyme alliinase immediately converts non-active alliin into the active ingredient, allicin.

As I mentioned, it was once thought that allicin was garlic's principal active ingredient. However, researchers now know that allicin is rapidly oxidized. In the process of oxidation, allicin breaks down into more than 100 biologically active sulfur-containing compounds. While allicin may still serve as a general marker of garlic's potency, research increasingly points to S-allylcysteine and other compounds as the most therapeutically active ingredients in garlic.

So how many possible pathogenic defense combinations can you get from garlic's 100 biologically active compounds? A whole bunch!! Thousands and thousands and thousands, in fact!

The formula for finding the number of combinations of k objects you can choose from a set of n objects is:

n_C_k = ----------
             k!(n - k)!

With 100 objects/compounds to work with and possible combinations ranging from any 2 of them to any 99 of them, the complexity is just far, far, far too much for simple pathogens to evolve around.

And that's the secret. But it gets even better.

When you combine several natural substances in one formula, the combinations of compounds are beyond counting. Quite simply, microbes cannot evolve around them.

Natural Antipathogenic Formula

Several weeks ago, I upgraded my antipathogen formula. It contains nine of the most powerful antipathogens found in nature.

  1. Ginger
  2. Onion
  3. Garlic (equivalent to 30 cloves in every bottle)
  4. Olive leaf
  5. Horseradish
  6. Habanero
  7. Zinc
  8. Wild mountain oil of oregano
  9. Apple cider vinegar

Individually, their effectiveness is astonishing.


Garlic is one of the best infection fighters available for both bacterial and viral infections. It is a natural antibiotic that does not appear to create resistant bacteria strains. In addition, fresh garlic extract has been shown to be virucidal to many viruses.

Garlic possesses the ability to stimulate the immune system. It can stimulate the activity of the macrophages (white blood cells), which engulf foreign organisms, such as: viruses, bacteria, and yeast. Furthermore, garlic increases the activity of the T-helper cells (immune cells which are central to the activity of the entire immune system). Garlic may be particularly effective in treating upper respiratory viral infections due to its immune-enhancing properties and its ability to clear mucous from the lungs.

It destroys and/or inhibits various bacteria and fungi, with an antibacterial action equivalent to 1% penicillin. Garlic is effective against strep, staph, and even anthrax bacteria.


Everything that's been said about Garlic can be said about onion. Onions and garlic share many of the same powerful sulfur bearing compounds that work so effectively as anti-viral and anti-bacterial agents.


Ginger has been traditionally used to treat colds and flu. Chinese studies have shown that ginger helps kill influenza viruses (even avian flu), and an Indian report shows that it increases the immune system's ability to fight infection.

Olive Leaf Extract

Olive leaf extract has a long history of being used against illnesses in which microorganisms play a major role. In more recent years, a drug company discovered that in vitro (in a test tube), an extract from olive leaf (calcium elenolate) was effective in eliminating a very broad range of organisms, including bacteria, viruses, parasites, and yeast/mold/fungus.

Habañero and Horseradish

These are stimulants that quicken and excite the body. They energize the body (helping it to marshal its defenses against invading viruses). In addition, they help to carry blood to all parts of the body.

They are also diaphoretics and thus help raise the temperature of the body, which increases the activity of the body's immune system.

Horseradish, in particular, contains volatile oils that are similar to those found in mustard. These include glucosinolates (mustard oil glycosides), gluconasturtiin, and sinigrin, which yield allyl isothiocynate when broken down in the stomach. In test tubes, the volatile oils in horseradish have shown antibiotic properties, which may account for its effectiveness in treating throat and upper respiratory tract infections. At levels attainable in human urine after taking the volatile oil of horseradish, the oil has been shown to kill bacteria that can cause urinary tract infections, and one early trial found that horseradish extract may be a useful treatment for people with urinary tract infections.

Liquid Ionic Zinc

Like colloidal silver, liquid zinc is both anti-bacterial and anti-viral, but without the potential toxicity issues found with silver. Zinc is found in all body fluids, including the moisture in the eyes, lungs, nose, urine, and saliva. Proper zinc levels offer a defense against the entrance of pathogens. In the 1800's, surgeons used zinc as an antiseptic/antibiotic after surgery; they noted its amazing healing properties. Wounds would heal, at times, as quickly as 24 hours after an operation, without swelling, and scarring was barely noticeable after a short period of time.

Oil of Wild Mountain Oregano

Numerous studies have shown wild mountain oregano oil (not to be confused with the oregano found in your kitchen) to be a potent antimicrobial. It has been proven useful as an antiviral, antibacterial, and antifungal agent rivaling even pharmaceutical antibiotics such as streptomycin, penicillin, vacnomycin, nystatin, and amphotericin in its ability to eliminate microbes. Remarkably it accomplishes this without promoting the development of drug resistant strains and other problems often attributed to the use of standard antibiotics. In addition to this already impressive list of abilities Oregano Oil is also a powerful parasitic expellant.

Apple-Cider Vinegar

ACV (Apple-Cider Vinegar) serves several functions in this formula:

  • It's the tincture medium for the formula, as opposed to alcohol (which is the tincture medium in an immune tonic).
  • ACV is anathema to all kinds of germs that attack the throat. In effect, it acts like a sponge and draws out throat germs and toxins from the surrounding tissue.
  • And finally, ACV stimulates a condition called acetolysis in which toxic wastes that are harmful to the body are broken down and rendered harmless.


As I said above, individually, the effectiveness of these ingredients is astonishing. But taken as a whole, and when you consider the number of possible active biochemical combinations these 10 ingredients and their hundreds of biochemical compounds afford, it would take bacteria and viruses more time than the earth has left in existence to evolve their way around them.

Bottom line: I believe that this formula represents the best natural antipathogen option in the world today.


    Submitted by Jennifer Fletcher on
    April 13, 2011 - 1:05pm

    So can I buy this for you or can you give me the exact amounts that you use to make this formula? I have never made a tincture from apple cider before either.


    Hi Jennifer, for more details, check out the Supplement Recommendations Page.

    Submitted by GuestKim Carragher on
    April 13, 2011 - 2:36pm

    Great article and thank you. It would seem a great idea to add the use of Probiotics as well, especially in C-Dif. Heard of many great results from using a Naturopath prescribed Probiotic.

    Submitted by BaselineFoundation on
    April 21, 2011 - 2:43pm

    Hi Kim,

    Just be careful you do not mix herbs that kill bacteria with Probiotics because they cancel each other out.   We have many articles about Probiotics, but you should take them at a different time than any antibacterial formula.  Please read this article from Jon Barron:

    The Baseline of Health Staff

    Submitted by Ann Crockett on
    April 21, 2011 - 9:26am

    It would be good to try this formula in getting rid of candida and parasites.
    But, when I try things like this, my hair becomes very thin, because of hashimotto thyroid, plus on my scalp I feel things like little bee stings or many bugs crawling under my scalp . I've tried tea tree oil and it did not help with this. I don't know if it's toxins or candida or heavy metals.
    My doctor can't help me with this. Would you be able to help me with this?
    Thank you.

    Submitted by BaselineFoundation on
    April 21, 2011 - 2:47pm

    Hi Ann,

    Try a  search on "Thyroid" and you can see the list of articles on this topic that may help you.

    The Baseline of Health Staff

    Submitted by Dr Louis Vydelingum on
    June 27, 2011 - 4:24am

    You recommend resveratrol, but the phyto- oestrogen in it, could it be harmful to men or women. Advise

    Submitted by BaselineFoundation on
    June 27, 2011 - 12:06pm

    We asked Jon Barron about this, and his response was as follows:

    I assume you’re referring to the 1997 Gehm study that observed that resveratrol induced proliferation of the estrogen-dependent human breast cancer cell line T47D.(1) However, that study has subsequently been shown to be only theoretically true. In fact, subsequent studies have shown just the opposite – that in fact, resveratrol decreases the processing of estrogen into dangerous estrogen metabolites and, more importantly, blocks interactions between estrogen metabolites and cellular DNA.(2) The bottom line is that it appears that resveratrol has the ability to prevent the first step that occurs when estrogen starts the process that leads to cancer by blocking the formation of the estrogen DNA adducts.

    Hope that helps.


    1 Barry D. Gehm, Joanne M. McAndrews, Pei-Yu Chien, and J. Larry Jameson, "Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor." PNAS December 9, 1997 vol. 94 no. 25 14138-14143. <>

    2 Fang Lu, Muhammad Zahid, Cheng Wang, Muhammad Saeed, Ercole L. Cavalieri, and Eleanor G. Rogan. "Resveratrol Prevents Estrogen-DNA Adduct Formation and Neoplastic Transformation in MCF-10F Cells." Cancer Prev Res July 2008 1; <>

    Submitted by Agnes on
    May 7, 2012 - 11:35pm

    I read a report that women with breast cancer should not drink any alcohol at all, not even an occasional red wine because of the effect of alcohol on estrogen production. Is this related to the discussion?

    Submitted by Tanja Chester on
    September 17, 2011 - 4:52am

    Natural Antipathogenic Formula

    Is there a product, can't seem to find it, or is there a recipe?
    I have been tormented, tortured, and generally attacked by some weird virus that has been mutating and morphing into all sorts of symptons over the past six months. I have been trying every angle from acupuncture, to parasite treatments, to immune boosters, tinctures, garlic etc. to no avail. This gremlin won't let me out of its clutches. I am trying to stay positive, any help would be great.
    My symptons include, burning in muscles, icy cold sensations under skin of arms, biting & gnawing feelings in arms, stinging all over at times, you name it


    Submitted by BaselineFoundation on
    September 20, 2011 - 4:32pm

    Hi Tanja,

    For more details, check out the Supplement Recommendations Page.

    Submitted by Stephanie on
    December 14, 2011 - 1:14pm

    Tanya: I hope I'm not correct, but it sounds like Morgellons Disease. You can Google Morgellons Disease for a search. You'll do well to visit It's a forum of people who are searching for answers or have something to share about particular diseases. Also visit: AirCrap for a detailed discussion on how one gets Morgellons and what it's like for the person. Another site is BariumBlues for the same info. It's a tragic disease and they say there is no cure. I've been successful using some "alternative" sources. Stay away from chemtrails. The last two sites above will teach you about chemtrails, if you don't know already.
    I've been ill for almost two years, and I've experienced cycles with the disease. Most people feel the disease is not contageous, but this isn't certain. Basically it's a fungus and lots of different parasites on the skin and under the skin. Keep your body alkaline. I eat no processed foods, no meat, and no dairy, and it helps! Stay away from genetically modified foods or meats that are from animals that ate GMOs. Stay away from pesticides and chemicals. Many people who get Morgellons, formerly had Lyme Disease sometime in their life. I had Lyme in the 1980s, and more recently I was bitten by two spiders while sleeping in my bed. The vectors may have carried the disease. Learn to spot chemtrails and stay away. Do your homework on Morgellons before you consider going to a doctor. Doctors do more harm than good for Morgellons at this time. They diagnose the patient as delusional. They can't get paid without an ICD-9 number, so they tell you you're nuts. The CDC has recently given Morgellons a number, and the doctor may not be aware. I've chosen to not go to a doctor for that reason. I don't need the negative impact. You can also go to That site and others are good for research and up-to-date news. Good luck. Stephanie

    Submitted by VIRGINIA on
    October 8, 2011 - 6:29pm


    Submitted by Tom on
    February 4, 2012 - 4:31pm

    Could this be suitable replacement for the Four Thieves formula, an historic anti-plague remedy?

    Submitted by Guest on
    March 22, 2012 - 7:18am

    Please tell the name of this product as I don't see anything called Natural Antipathogenic Formula on the Supplement Recommendations Page.

    Submitted by BaselineFoundation on
    March 23, 2012 - 4:31pm

    Look for "Cold Busters"

    Submitted by Denver on
    April 8, 2012 - 8:24pm

    My 75 y.o. mother has persistant UTIs (Urinary Tract Infections), that come and go many times each year for the past several years. She takes antibiotics which seem to work by the time she finishes the prescription. Then the UTI invariably always comes back a week or two later & if she complains to her doctor, he may vary the antibiotic she takes the next time.

    She has heart disease, has had a shunt & a balloon put in this past decade, but she continues to (over)eat anything that passes in front of her. And she is about 35 lbs overweight & doesn't exercise hardly at all; to the contrary, she sleeps 10-14 hours a night due to being so tired from her heart condition. The heart disease and being overweight is bad of course, but the UTIs keep her awake throughout the night every night, urging her to get up to urinate every other hour. This makes her more tired, cranky & surely has/is affecting her immune system. She is exhausted and disillusioned.

    Would the Pathogen/Cold Busters formula work for her persistant UTI?

    For the past 25 years, I"ve eaten mainly organic, loads of raw garlic, ginger, lemongrass & other green superfoods daily & maintain a healthy lifestyle & weight. I've tried and tried to get her to adopt healthy(er) lifestyle habits but to little effect.

    Submitted by BaselineFoundation on
    April 11, 2012 - 3:39pm

    To better understand why antibiotics do what they do for your mother and why natural alternatives are different, you might want to read

    Hope it helps.

    Submitted by Mary on
    May 18, 2015 - 10:23am

    My mother is 93 and incontinent. Believe me, having a diaper full of stool was always a nightmare as she frequently developed a UTI soon afterwards. I had read about the use of cranberry pills and decided to try it. I give her one in am and one at bedtime. Everyday. She has not had a UTI in over 3 years. She use to get 4-5 or more every year. So thankful for these pills!

    Submitted by Veta Francis on
    August 12, 2013 - 9:42am

    Hi Dr. Baron,
    How can I get this, Natural Antipathogenic Formula.

    Submitted by BaselineFoundation on
    August 12, 2013 - 10:17am

    Hi Veta, 

    All formula recommendations are on our product page.  Just scroll down and look for the company that is listed.  This one is at Baseline Nutritionals.

    Submitted by trish on
    October 12, 2014 - 11:23am

    How can I get ahold of a researcher on MRSI. My son can not get rid of this and ends up in the Hospital for days. We live in S Cal and yes her does surf.

    Submitted by SHARON on
    March 15, 2016 - 7:25pm
    DURANGO , Colorado


    Submitted by BaselineFoundation on
    March 18, 2016 - 2:28pm

    You should follow the Baseline of Health program.  The best is to just read Jon's book, you can download it for free, see above.  Click the "free book" button at top under our logo.

    Submitted by Minime on
    November 18, 2016 - 5:34pm
    Canada ,

    Hi there. I have been on nystatin and genestra candida clear four for a week. I have been deathly ill since taking amoxicillin for a tooth infection which was only tooth pain from having already a sinusitis fungal infection and then making it much worse. I have olive leaf extract at home and would like to add it to my daily medication and even replace the nystatin if possible. I have started neti pot and colloidal silver rinse as of yesterday but look foward to feeling better a lot faster than I currently am.

    Submitted by Mary on
    June 16, 2018 - 11:33am
    Fredonia , New York

    Dear BaselineFoundation, I am suffering with what is being called chronic fatigue syndrome. I have basically lost half my life at 51 yrs. old. I am chronically fatigued and have fibromyalgia. Sometimes I do wonder if I have Lyme even though testings have been negative. I am positive for cytomegalovirus and did have EBV in 2003 but recovered and was fine in about 4-6 months. Do you have any persons helped with this type of health issue from one of your products and if so which would be best for my situation. I take one 20% olive leaf daily and never get any type of cold.
    Thanks for your time and attention, Mary

    Submitted by BaselineFoundation on
    June 21, 2018 - 5:53pm

    Hi Mary,

    For obvious legal reasons, we can not diagnose or prescribe, merely provide information.  I would do a search on our website for these topics and see what the articles suggest for each one.


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